Best trans-Resveratrol 200 features ResVinol-25, a proprietary extract providing concentrated
levels of polyphenols and trans-resveratrol from red wine matrix and the root of the Japanese
knotweed (Polygonum cuspidatum) plant. Resveratrol exists in both trans- and cis-forms. However,
published research suggests that only the trans- form has valuable biological activity.
ResVinol-25 is a high-quality extract subjected to rigorous ProfileProven analytical and quality
assurance procedures designed to ensure potency and purity of the extract from batch to batch.
The product is extensively tested for heavy metals, bacterial and fungal contaminants, and
pesticides to verify purity and compliance with acceptable standards.
Supports Immune System Function*
Promotes a Normal, Balanced Inflammatory Response*
A summary report on resveratrol noted that its ability to modulate immune function and promote a
balanced inflammatory response works not through one simple mechanism, but through several
complex pathways. As shown in mice, resveratrol inhibited the TNF-alpha cytokine pathways that
are critical in regulation of immune cells. Resveratrol can inhibit inflammatory enzymes and the
synthesis of pro-inflammatory mediators and eicosanoids. In mouse mast cells, resveratrol
inhibited TNF-alpha and histamine release, in turn blocking production of unfavorable
eicosanoids. In lung cells, resveratrol appears to inhibit macrophage release of IL-8 chemokines
in vitro, limiting overreaction of white blood cells. An in vitro study conducted with human
polymorphonuclear leukocytes (or PMN-L, a type of white blood cell) showed that even tiny
amounts of resveratrol specifically inhibited the formation of pro-inflammatory metabolites of
arachidonic acid.
Supports Cardiovascular Health*
Enhances Cerebral Circulation*
The "French Paradox" has led to extensive research into the physiological effects of the
bioactive components of red wine-the active ingredients in Best trans-Resveratrol. To build on
evidence of the potent cardiovascular effects of resveratrol seen in animal studies, the focus
has now shifted to working with human samples. In 20 healthy adults examined before and after 15
days of controlled wine consumption, an increase in blood nitric oxide (NO) production was
reported.8 Nitric oxide is a gas responsible for signaling the smooth muscle in blood vessels to
relax, thus promoting healthy circulatory function. In a particularly convincing study using
blood vessel tissue derived from humans, resveratrol promoted nitric oxide-induced vascular
relaxation and overall enhanced endothelial (blood vessel) function.
Results from a cutting-edge crossover study published in 2010 provide exciting new evidence of
other possible benefits of resveratrol supplementation. In this randomized, double-blind,
placebo-controlled investigation, 22 healthy adults each received placebo, 250mg trans-
resveratrol, and 500mg trans-resveratrol on separate days. In a dose-dependent fashion,
supplementation with trans-resveratrol resulted in higher cerebral blood flow in the prefrontal
cortex during cognitive tasks (compared to placebo). The researchers also measured the
bioavailability of their supplements, confirming that resveratrol and its metabolites were
present in the blood following supplementation at both doses. They concluded that resveratrol,
when taken orally, can influence brain function.
Facilitates Potent Antioxidant Activity*
Supports the Integrity and Activity of Neuronal Cells*
Although the mechanisms behind all its actions are not yet fully understood, resveratrol is
revered for its antioxidant functions. Scientists do know that resveratrol counters lipid
peroxidation both by the chelation of copper and the quenching of free radicals. In one of many
in vitro trials investigating its antioxidant functions, trans-resveratrol worked at 95%
efficiency to deter lipid peroxidation. Under the same oxidative stress load, vitamins E and C
worked at efficiencies of only 65% and 37%, respectively. In a 2010 study, researchers observed
resveratrol's action on erythrocytes (red blood cells) derived from 23 healthy volunteers. When
the erythrocytes were subjected to oxidative stress, resveratrol protected the cell glutathione
levels-evidence of protection from oxidative stress.
Numerous studies have examined the role of resveratrol in protecting the nervous system from
oxidative damage. In one such study the researchers examined resveratrol's action on in vitro
brain cell samples and noted less depletion of the antioxidant glutathione, less accumulation of
oxidative agents, and less neuronal damage. These scientists also noted a protective role from
sirtuin activity, revealing that the benefits of resveratrol in this scenario can be
multifactorial. In a recent study, resveratrol prevented an increase in acetylcholinesterase
activity in rats, which helped preserve their cognitive function-memory in particular. These
observations led to conclusions that resveratrol may help ameliorate oxidative stress that
occurs in several areas of the brain, thereby influencing neurotransmission. Several previous
studies, such as one showing preserved cognitive function in rats (presumably from resveratrol's
antioxidant activity), build a strong case for the usefulness of resveratrol in supporting brain
function in mammals.
Promotes Healthy Aging*
May Enhance Healthy Glucose Metabolism*
Perhaps the most intriguing aspect of resveratrol activity is its apparent ability to increase
the longevity of numerous species-ranging from simple organisms, like yeast, to those with
complex genomes, like mice. In several organisms, both caloric restriction and resveratrol
consumption have demonstrated the ability to activate sirtuins, a group of proteins that have
been linked to aging, metabolism, and cellular stress tolerance. Activation of sirtuins is a
proposed mechanism behind resveratrol's apparent ability to extend the lifespan of yeast, worms,
fruit flies, and vertebrate fish. Since dietary restriction in humans can in many respects lead
to a higher quality of life during the aging process, the prospect of a compound that mimics
this dietary restriction garners great attention in the scientific community.
A groundbreaking study published in 2006 demonstrated the ability of resveratrol to shift the
physiology of mice consuming excess calories (including some of the health concerns instigated
by excessive diets) to one of mice consuming a standard diet-all without significant changes in
body weight. In simpler terms, the resveratrol enabled the overeating mice to have a level of
health enjoyed by mice that ate a proper diet. In a subsequent study using mice, researchers
concluded that resveratrol seemed to mimic the effect of a restricted-calorie diet at the
transcriptional (genetic) level, and was able to benefit tissues of the heart, liver, and muscle
in a manner similar to dietary restriction. These results are reinforced by yet another study
where researchers found that, in mice, a low dose of resveratrol mimicked the effects of a
restricted-calorie diet on gene expression in vital organs that affect aging; however, the
researchers concluded that in this case it was due to factors other than influence on sirtuins.
More research is needed to fully comprehend how resveratrol works, but the volumes of papers
published attest to the multifaceted wonders of resveratrol and its companion red wine phenolic
compounds.
Lastly, it should be mentioned that a good deal of interest has been generated by the apparently
favorable actions of resveratrol on glucose metabolism, as seen in animal studies. A recent in
vitro study demonstrated trans-resveratrol's influence on how skeletal muscle responds to
glucose, presumably through the action of sirtuins. Furthermore, a 2010 in vitro resveratrol
study even shows positive metabolic interactions with human fat cells. While the implications of
results like these are provoking, clinical trials need to be conducted to determine the degree
of practicality for such uses of resveratrol.
In sum, more research is needed to fully comprehend how resveratrol works inside the human body,
but the volumes of in vitro and in vivo data attest to the multifaceted potential of the
compounds found in a bottle of Best trans-Resveratrol.
Supplement Facts:
Serving Size: 1 capsule
Servings Per Container: 60
Amount Per Serving % Daily Value *
Trans-Resveratrol 200 mg *
Polyphenols 80 mg *
(from red wine matrix (Grape (Vitis vinifera)) and Japanese
Knotweed (Polygonum cuspidatum))
* Percent Daily Value not established.
Other ingredients:
Rice flour, silicon dioxide, magnesium stearate (vegetable source).
Directions:
Take 1 or more capsules daily with meals.
Warnings:
KEEP AWAY FROM CHILDREN. Most studies have shown that resveratrol is rapidly absorbed and
metabolized in humans. In a 2010 review of safety data from human studies that administered
resveratrol at high doses, no serious side effects were reported. Although long-term data is not
available for humans, long-term resveratrol supplementation at moderate to high (but not
extremely high) doses in rodents did not produce side effects. Because human research is
limited, pregnant women should check with a physician prior to using the product.
Does Not Contain:
Milk, egg, wheat, gluten, corn, soy, sugar, sweeteners, starch, salt, or preservatives
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