Best Hyaluronic Acid wth Chondroitin Sulfate contains patented BioCell Collagen II (US patents
6,025,327; 6,323,319; & 6,780,841). BioCell Collagen II is sourced from chicken sternal cartilage
and provides bioavailable, low molecular weight hyaluronic acid. It is standardized to contain 10%
Hyaluronic Acid, 20% Chondroitin Sulfate, and 60% Collagen Type II.
Hyaluronic Acid and Collagen are vital structural components of the skin that decline as we age,
and are partly responsible for the skin's moisture, suppleness and elasticity. BioCell Collagen II
contains key components that can help support healthy skin and joint function*.
BioCell Collagen is hydrolyzed and denatured to low molecular weight compounds that increase the
bioavailability and absorption of its components. In an absorption study of BioCell Collagen,
measurements revealed a gradual and significant increase of active total Hyaluronic Acid (HA) in
the blood of test subjects after a single dose. In the same study, subjects taking BioCell
Collagen for 28 days maintained elevated blood levels of HA compared to initial levels.
The components of Best Hyaluronic Acid with Chondroitin Sulfate are naturally found in human
cartilage, and they have all been the topics of intense research in joint health over the past few
decades. Collagen and hyaluronic acid are also vital structural components of skin that decline as
we age, influencing our skin's moisture, suppleness, and elasticity. BioCell Collagen can help
replenish the body's natural supply of these components, which in turn can support healthy skin
and joint function.
Hyaline Cartilage: Of Particular Interest As We Age
Acting as an efficient load-bearing surface for our freely movable synovial joints, articular (or
hyaline) cartilage becomes a point of concern as we age: As a part of normal physiology, the
tensile properties of this cartilage begin to decline after about age 30. Many factors come into
play when considering healthy mechanical function of this invaluable tissue, not the least of
which is structural composition. Hyaline cartilage is composed mainly of water, proteoglycans, and
collagen (primarily Type II collagen). Attached to the protein core of proteoglycans are the
glycosaminoglycans keratan sulphate and chondroitin sulfate, which have the important function of
binding large amounts of water to work against cartilage compression. The proteoglycans can bind
to a hyaluronic acid backbone to form larger molecules, adding to the solid portion of articular
cartilage-essentially a dense network of type II collagen fibers embedded in a highly concentrated
matrix of aggregate proteoglycan molecules.
Supports Healthy Joint Structure and Function*
Components of BioCell Collagen (collagen type II, chondroitin sulfate, and hyaluronic acid) can
enhance the normal production of proteoglycans in the joint matrix, thereby enhancing healthy
joint structure and helping to maintain joint shock absorption and cushioning. In a randomized,
double-blind, placebo-controlled pilot study exploring the safety and effectiveness of BioCell
Collagen® towards joint health, 16 subjects were enrolled to receive 2 grams of BioCell or placebo
daily for 8 weeks. The subjects who were administered BioCell demonstrated significantly greater
joint comfort, mobility, and quality of life over time, compared with placebo.
Collagen Type II
The benefits of collagen type II in safely supporting healthy joint and skin function have been
examined in both animal and clinical studies. A randomized controlled trial conducted on 60
volunteers found that oral administration of chicken collagen type II for 3 months led to a
significant increase in healthy joint structure, as compared to no measurable improvement in the
placebo group. In another double-blind, placebo-controlled trial, 274 individuals were given
collagen type II orally for 24 weeks. The supplement was shown to support healthy joint function,
and no adverse effects were observed during this comprehensive clinical trial. Other studies have
shown that hydrolyzed collagen provides a substantial advantage in bioavailability over non-
hydrolyzed collagen, thereby having the potential to enhance healthy joint structure more
efficiently.
Chondroitin Sulfate
Chondroitin has been extensively researched for its ability to help maintain joint structure and
function. In a review of high quality studies that included 1,443 research volunteers, long-term
administration of oral chondroitin sulfate promoted knee comfort and overall motility, while also
proving to be safe and well tolerated. On a biochemical level, chondroitin sulfate is believed to
supply building blocks for proteoglycan synthesis and to hinder matrix metalloproteases (MMP) that
are key proteases capable of degrading a range of matrix components in cartilage. Although the
methods of action are not yet fully understood, the positive effects of chondroitin sulfate on the
chondrocytes (cartilage cells), synovial membranes, and subchondrial bone of joints have been
demonstrated in research. The immunomodulatory effects in articular cartilage, such as inhibiting
activation of the transcription factor NF-kB, appear to be a primary action by which chondroitin
enhances joint comfort.
Hyaluronic Acid
Hyaluronic Acid (HA) is a type of building block called a glycosaminoglycan, and it plays an
important role in supporting the structural strength of connective tissue and cartilage. Healthy
connective tissue and cartilage maintenance is fundamental in normal skin and joint function. HA
is highly concentrated in synovial fluid, where it serves to enhance joint lubrication and the
elastic structural and functional characteristics of the joint. In 2007, a study with 98
participants determined that a healthy concentration of HA in synovial fluid is a strong indicator
of joint health. Since the body's supply of HA naturally decreases with age, Best Hyaluronic Acid
with Chondroitin Sulfate has been formulated to help maintain healthy HA levels, allowing for the
extended maintenance of joints and skin.
Helps Maintain Youthful Skin*
HA also plays an important role in maintaining the health and natural beauty of the skin. The
compound enhances the structure and volume of the skin by promoting healthy connective tissues
that interact with the skin. HA plays a direct role in the attraction and maintenance of moisture
in the skin; as HA concentrations naturally decrease in the elderly, it may become difficult for
the skin to retain moisture, leaving the skin dry and uncomfortable. Researchers have performed
comparative measurements of hyaluronic acid levels in the skin of young and elderly individuals.
Results indicate that there is a normal and progressive reduction in the number of hyaluronic acid
granules in human skin with age-so much of a reduction, in fact, that a complete absence of these
granules was seen in healthy individuals 60 years or older. These variations in HA levels with age
may account for the decreased turgidity, wrinkled appearance, and altered elasticity of skin
tissue. Recent in-vitro laboratory studies are now indicating that HA not only provides moisture
retention and structural support to the skin, but also promotes cellular vitality. The results of
one such study indicate that HA given to human epidermal (skin) cells induces cell signaling that
promotes natural cell repair and tissue renewal.
Supplement Facts:
Serving Size: 2 capsules
Servings Per Container: 90
Amount Per Serving % Daily Value *
BioCell Collagen II, providing: 1000 mg *
Hyaluronic Acid 100 mg *
Chondroitin Sulfate 200 mg *
Hydrolyzed Collagen Type II 600 mg *
* Percent Daily Value not established.
Other Ingredients:
Rice powder, gelatin (capsule), magnesium stearate (vegetable source).
Directions:
Take 2 capsules daily, or as directed by a health care practitioner. Take with or without
food.
Warnings:
KEEP OUT OF REACH OF CHILDREN. BioCell Collagen achieved GRAS (Generally Recognized As Safe)
self-affirmation, meaning that a consensus on safety was reached by an independent expert panel of
qualified scientists who carried out an extensive review of all available scientific safety data
on this ingredient.
The BioCell Collagen in Best Hyaluronic Acid with Chondroitin Sulfate provides a safe, natural,
standardized source of building blocks useful for maintaining joint structure and function, as
well as promoting the integrity of healthy skin.
Does Not Contain:
Milk, egg, wheat, gluten, corn, soy, sugar, sweeteners, starch, salt, or preservatives
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